Hyaluronic acid is one of those ingredients that might “sound trendy,” but it has actually earned its reputation: science supports it and the skin appreciates it, as it helps maintain hydration and promotes a plumper, healthier-looking complexion. Here’s a clear guide to understanding what hyaluronic acid is, why it stands out so much, and what benefits it can bring to your facial care routine.
What hyaluronic acid is and why it’s key for skin hydration
Hyaluronic acid (HA) is a molecule naturally present in our body, especially in the skin, where it acts as a reservoir of hydration. Its ability to attract and retain water helps keep the skin stable, hydrated, and comfortable, while also providing a subtle superficial plumping effect and smoothing the skin’s texture.
Is the hyaluronic acid in cosmetic products the same as the one used in aesthetic fillers?
No. Although the base molecule is the same, hyaluronic acid differs in its form, concentration, structure and, above all, in the purpose for which it is used.
In topical cosmetics, it works on the surface of the skin to attract water, improve hydration, strengthen the skin barrier and provide a plumper, more comfortable feel. In aesthetic medicine, however, it is used as an injectable gel to fill wrinkles, restore volume and redefine facial contours from deeper layers of the skin.
Benefits of hyaluronic acid for the skin
Hyaluronic acid stands out for its visible results thanks to its property as a high-performance humectant. These are the benefits you can usually expect with consistent use:
- Immediate and long-term hydration.
- “Plump” effect: skin looks juicier and healthier.
- Reduction in the appearance of wrinkles and expression lines.
- Improved comfort: increased skin elasticity.
- Improved barrier function.
Although it does not act as a structural filler, hyaluronic acid visibly improves skin hydration and the appearance of fine lines, providing radiance, softness and a sensation of more elastic skin.
Types of hyaluronic acid and why molecular weight matters
Not all hyaluronic acids behave the same way. That’s why many formulas combine different molecular weights to achieve more complete hydration.
| Type (indicative) | What does it usually provide? | Ideal if you’re looking for… |
|---|---|---|
| High molecular weight | Surface film that prevents water loss | Immediate hydration and a “plump skin” feeling |
| Low molecular weight | Penetrates superficial layers and retains water | Greater elasticity and longer-lasting hydration |
| Very low molecular weight | Hydration in deeper layers of the stratum corneum | Greater plumping effect and improved appearance |
| Hydrolyzed | Stimulates the formation of new endogenous hyaluronic acid and provides multi-layer hydration | Improves signs of aging and overall skin quality |
At Sesderma, our formulas combine different molecular weights of hyaluronic acid to provide multi-layer hydration. In addition, thanks to Sesderma’s proprietary Nanotech technology, active ingredients reach deeper levels of penetration and effectiveness in the skin.
How to use hyaluronic acid in your facial care routine
The most common mistake isn’t the ingredient itself, but the way it’s used.
Do you need to dampen the skin before applying hyaluronic acid?
No. In cosmetic formulas, this ingredient is already hydrated within the formulation itself and, as a hygroscopic substance, it works like other humectants by attracting and retaining water. The key is not adding extra water before applying it, but rather using a moisturizer afterward that helps reduce evaporation and maintain hydration.
If you feel it works better when applied to damp skin, it may simply be a sign that your skin was previously dehydrated.
Should hyaluronic acid be applied in the morning or at night?
The practical answer is that you can use it morning and night. In the morning, it provides hydration and prepares the skin for sunscreen, while at night it supports the skin’s overnight repair and improves comfort.

Recommended order in your routine
Remember to start with the lightest texture and finish with the densest. A simple and effective routine could be:
- Gentle cleanser: clean skin without stripping.
- Hydrating mist / thermal water or toner (alcohol-free, optional).
- Hyaluronic acid serum: a couple of drops.
- Moisturizing cream: seal hydration and reinforce the barrier.
- In the morning: sunscreen — essential.
A balanced routine combines humectants, emollients and occlusives to better maintain skin comfort.
Effects of hyaluronic acid
Hyaluronic acid usually provides immediate improvement (comfort and plumpness) and progressive improvement in texture and the appearance of fine lines with consistent use.
- First applications: softer, more flexible and more comfortable skin.
- 2–4 weeks: more even texture, improved elasticity and better radiance.
- Continuous use: improved skin hydration balance and less noticeable expression lines.
Who is hyaluronic acid for?
Hyaluronic acid is a very versatile ingredient that is generally well tolerated by all skin types. Choose the texture that best suits your skin type and incorporate it into your routine.
Dry or dehydrated skin
This is where it truly shines. Combine it with a cream that provides lipids and reinforces the barrier function, because hydration is not the same as nourishment. This helps prevent rapid water loss.
Combination or oily skin
Yes, it can be used. In fact, oily skin can also be dehydrated. In this case, a lightweight serum and an appropriate moisturizer are ideal to avoid heaviness while maintaining hydration without a greasy feel.
Sensitive or reactive skin
It is usually a safe option since it is naturally present in the body; however, everything depends on the full formula. If your skin is very sensitized, prioritize simple and consistent routines. The goal is to soothe and strengthen the barrier before adding too many active ingredients.
Common mistakes when using hyaluronic acid (and how to avoid them)
If you feel like it “doesn’t work”, there is usually a simple reason. These are common mistakes and the practical adjustment:
- Confusing hydration with a complete anti-aging treatment: it’s a key piece, not the entire routine.
- Expecting it to fill deep folds: it improves fine expression lines, not structural features.
How to choose a product with hyaluronic acid: serum vs cream
Both options are good and deliver the ingredient appropriately to your skin. The choice mainly depends on your skin type, needs and where it fits in your routine. The hyaluronic acid serum usually provides lightweight, fast and concentrated hydration, while a cream with hyaluronic acid, in addition to hydrating, helps seal moisture and maintain comfort for longer.
Quick questions that often come up in consultation
Can I combine hyaluronic acid with vitamin C or retinol?
Yes. Hyaluronic acid works very well as a support ingredient because it improves comfort, which is helpful when using stronger actives. The practical rule is to maintain the correct order: apply lighter textures first and finish the routine with sunscreen.
How many times a day should it be used?
Usually 1–2 times a day.
Does it help with dark spots?
Hyaluronic acid is not a depigmenting ingredient. It can help the skin appear more even due to improved hydration, but if your main concern is pigmentation, it is best to combine it with specific depigmenting actives and, above all, consistent sun protection.
If hyperpigmentation concerns you, you might also be interested in: Which anti-blemish cream do dermatologists recommend?
If there is one takeaway, it is this: hyaluronic acid is a “base” ingredient that improves skin quality through hydration. Seeing results does not depend on luck, but on consistency and choosing the right formula for your skin.
